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IGF-1 signaling influences immune cell development and function in research models, and LR3 has been used to probe these effects without the complicating IGFBP biology that would confound native IGF-1 experiments

Research reported in this publication was supported by the National Cancer Institute of the National Institutes of Health under award number R21CA252441 (to AY and RC at CUIMC transferred to AY at MUSC), R01DK124553 (to AK), F30DE033286 (to CK), and Hollings Cancer Center Support Grant (P30 CA138313)

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