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In addition to the highly organized and regulated immune system, there are specific immune cell populations that exist in the CNS that are vital in maintaining normal brain homeostasis and function

Just like the gut, the brain can also be leaky. Like the stomach barrier, the blood-brain barrier is lined with one layer of cells that separate the blood from the brain

Y., Iijima, K., Nishida, A

Activated microglia and astrocytes release proinflammatory cytokines, chemokines, and reactive oxygen species, contributing to synaptic dysfunction and neuronal death (Thakur et al., 2023)