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NF-B in biology and targeted therapy: New insights and translational implications

doi: 10.3390/ijms241310770 101

Data on new targeted therapies are even more promising: vedolizumab, as a gut-specific anti-integrin, has demonstrated a rare incidence of severe adverse events in registered trials, open extensions, and real-world data, while remaining safe in pregnant patients, children, the elderly, and those with a history of cancer [334]