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It upregulates peroxisome proliferator-activated receptor gamma coactivator 1 alpha, the master regulator of mitochondrial biogenesis, which in turn stimulates mitochondrial proliferation [138]

It also produces a post-caffeine crash that adds a second energy trough to an already depleted morning

NAD+ metabolism and the control of energy homeostasis - a balancing act between mitochondria and the nucleus

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L.ScacciaL

This route is favored according to the metabolic necessities of cells