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The efficacy of chemoradiotherapy for this disease is uncertain, but there is some literature suggesting that stereotactic radiotherapy can be used to treat this disease, but more evidence-based evidence is lacking [8, 9]

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Possibly related to chronic minor irritation , chronic biting, friction or sun exposure (for lip lesions), although this link is not consistent

Salvage treatments were used in 69.7% of patients after ipi3, 51.6% of patients after ipi10, and 86.2% of patients after HDI