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Among the 122 proteins downregulated in PQS-treated shCNMT RAW264.7 macrophages, the iron uptakeassociated single-pass membrane receptor TFR1 was directly related to ferroptosis as the critical downstream effector of CNMT 15

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10.1038/s41598-019-53154-w 24 FengT.NiuJ.PiB.LuY.WangJ.ZhangW.et al (2020)

However, our preliminary study (unpublished) indicates that extracellular ligand-binding domain is required for this EGF receptor transactivation