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The specific treatments and outcomes displayed in eTable 4 in the Supplement include: 1) medication or system injection (i.e., analgesics, antidepressants, new immune modulator, old immune modulator), 2) instillation (i.e., botulinum toxin [BTX], sodium chondroitin sulfate [CS], sodium hyaluronic acid [HA]), 3) intravesical injection (i.e., BTX, RTX, anesthetics), 4) physical therapy (i.e., radiofrequency, nerve stimulation), 5) others (i.e., dietary, hydrogen-rich water, video intervention)

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Peptides offer high specificity, lower offtarget effects, and lower immunogenicity compared to some biologics/small molecules