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This review systematically describes the metabolic pathways of ferroptosis and summarizes the mechanisms of action of natural and synthetic small-molecule inhibitors of ferroptosis as well as their applications in disease

In a long-term randomized, double-blind, placebo-controlled study among sufferers of cerebrovascular accidents at high risk of depression, daily supplementation with 2 mg of folic acid, 25 mg of vitamin B6, and 500 g vitamin B 12 significantly lowered the risk of major depressive episodes during a seven-year follow-up period compared to placebo (111)

Among microbiota-based interventions, FMT exerts the most extensive metabolic effects, but the precise outcome heavily relies on the donors microbial profile

[1] This effect is dose related

Restricting cysteine, depleting GSH, or inhibiting GPX4 can increase phospholipid peroxidation in responsive cells, but sensitivity also depends on lipid composition, iron metabolism, parallel antioxidant systems, and tissue context (Jiang et al., 2021)

A deficiency in this essential vitamin is often easily noticeable