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Saulle E, Spinello I, Quaranta MT, Pasquini L, Pelosi E, Iorio E, Castelli G, Chirico M, Pisanu ME, Ottone T, Voso MT, Testa U, Labbaye C (2021) Targeting lactate metabolism by inhibiting MCT1 or MCT4 impairs leukemic cell proliferation, induces two different related death-pathways and increases chemotherapeutic sensitivity of acute myeloid leukemia cells

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Indeed, the co-treatment of glioma cells with SC79 (AKT activator) and MPEP (mGluR5 antagonist) reverses the effect of the mGluR5 inhibition in glioma cells, indicating that AKT as a downstream of mGluR5 can regulate cell viability in hypoxia and normal conditions (75, 76)