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5.1 Mechanism of intranasal delivery Since William Frey II proposed intranasal administration in 1991 (Frey, 1991), this technique has emerged as a novel, non-invasive delivery system, bypassing the BBB and the systemic first-pass effect, allowing rapid onset of action

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[7] Reviews additionally describe effects on elastin and on the balance of matrix metalloproteinases against their tissue inhibitors, though these are secondary summaries rather than primary human-tissue datasets

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The pathogenic symphony in type 1 diabetes: a disorder of the immune system, cells, and exocrine pancreas