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Crystallization of water during freezing and subsequent thawing can mechanically damage the peptide structure

Pale or jaundiced skin Due to the problems that low levels of B12 cause to the bodys red blood cell production, a common symptom of B12 deficiency is looking pale

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In further embodiments, the invention encompasses a method of inhibiting NNMT in vitro or in vivo by contacting a cell expressing NNMT with one or more cations chosen from 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, 2aa, 1c, 1f, 1l, 1m, 2j, 2k, 2l, 2m, and 2aa