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[53] M6P F6P Regulation of glycolysis The flux of carbon through the glycolytic pathway is tightly regulated in response to metabolic conditions , both intracellular and extracellular, in order to satisfy two major needs: the production of ATP

Then, 1.5 M Oligomycin, 0.5 M FCCP and 0.5 M Rotenone/0.5 M Antimycin A mix were sequentially injected to measure mitochondrial activity

Jiang W, Hou X, Qi Y, Wang Z, Liu Y, Gao XJ, Wu T, Guo J, Fan K, Shang W

Combining metabolic inhibitors with immunotherapiessuch as glycolytic inhibitors with checkpoint modulatorsrepresents a promising strategy to reestablish immune balance in autoimmune and inflammatory diseases

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In order for a molecule to act as a signal, its concentration should be low and un-buffered, such that perturbations may induce large variations in its pool size