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Deubiquitination of active NLRP3 triggers ASC aggregation and the recruitment of precaspase-1, which leads to the formation of the NLRP3 inflammasome and the release of proinflammatory cytokines such as IL-1 and IL-18

The autophagy adaptor p62/SQSTM1, essential for targeting ubiquitinated substrates to autophagosomes, is mutated in ALS and FTD, where impaired p62 function results in aggregation-prone protein accumulation and neuronal toxicity

(iii) history of seizure disorder or gross neurological deficit

doi: 10.1016/j.scienta.2008.07.016 93 KousarS.AhmedF.PervaizA.Bojnec

B12 Vitamin B12 is a water-soluble vitamin that helps keep the bodys nerves and blood cells healthy

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