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however, none of them has yet been translated to clinical use, possibly due to their low binding affinity and impermeability to the blood-brain barrier

doi: 10.1038/jcbfm.2012.30 201 WangYLiJWangMYPanZYLiZQWangZF

Couto JP, Moreira R

Since it comes as a sterile powder that must be reconstituted before use, it is strictly administered by a qualified healthcare professional

In accordance with our immunoblot experiments, no significant reduction of the RNF4 protein level was detected upon treatment of cells with the PROTACs