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4D and Supplementary Fig

-glutamyl transpeptidase accelerates tumor growth and increases the resistance of tumors to cisplatin in vivo

A small study utilizing M-SHIME (a simulator of the human intestinal microbial ecosystem) demonstrated that probiotic supplementation could significantly alter bacterial composition and improve gastrointestinal health in PD patients

However, during the fibrotic phase, M1 macrophages are transformed into M2 macrophages with anti-inflammatory functions, further accelerating pulmonary fibrosis development [34, 39]