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These reports showed that the percentage of young adults aged 18 to 25 who had ever used cocaine was below 1% during the mid-1960s

10.1016/j.cell.2020.09.020 231 YuJ.ChenM.HuangH.ZhuJ.SongH.ZhuJ.et al (2018)

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Furthermore, accumulation of monocyte-derived macrophages resulted in the overexpression of ALOX5 and the accumulation of its metabolite LTB4, which activates the expression of ACSL4 to accelerate ferroptosis and tissue injury in COPD[210]

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