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Increased carbamylation has been linked to complications of chronic renal diseases, including renal fibrogenesis, cataracts, and rheumatoid arthritis [66,67]

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doi: 10.3390/pharmaceutics16121625 192 ZhangXWangSTangKPanWXuHLiYet al

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In supplement form, it is used by healthy adults to support general wellness, particularly in areas like digestive balance, mobility, and overall tissue function

Current research focuses on counteracting HO-1-mediated ferroptosis through the following strategies: using HO-1 inhibitors (e.g., zinc protoporphyrin-IX (ZnPP)), ferroptosis inhibitors (e.g., ferrostatin-1, iron chelators), modulating key signaling pathways (e.g., targeting the Nrf2/Keap1 axis), and microRNA-mediated inhibition (e.g., miR-24, miR-200c) (69)