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They took neurons from two areas of the murine nervous system, the dorsal root ganglion, and the trigeminal ganglion, and studied them using calcium imaging

Specifically, there were fewer inhibitory neurons and an excess of glial cells, causing heightened electrical activity and neuronal hyperexcitability

McGuire FP et al

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Severe Anxiety or Agitation: Phentermine stimulates the central nervous system, which can exacerbate symptoms of anxiety and restlessness

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