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The safety profile of cagrilintide-semaglutide was broadly consistent with that reported for other incretin-based therapies, although gastrointestinal adverse events and treatment discontinuations occurred more frequently than with either semaglutide or cagrilintide alone, highlighting the importance of careful patient selection and long-term adherence

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[oai_citation:1PubMed]( 2) Nitric-oxidemediated, largely endothelium-dependent vasorelaxation Aortic ring experiments showed vasodilation that was blunted by L-NAME and hemoglobin and attenuated without endotheliumconsistent with NO-mediated effects