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doi: 10.3389/fimmu.2017.00356 116 AhernDJBrennanFM

DMSO and MSM were first used in labs as solvents, but as scientists experimented with using DMSO as a medicine, they also experimented with MSM

After the formation of a ligand-receptor complex, it diffuses laterally in the plasma membrane until encountering a coated pit, where the receptor-ligand complex accumulates with clathrin, adaptor protein, and dynamin