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coli (DIZ 8.07 mm) and high cytotoxicity (brine shrimp nauplii bioassay)

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Fujimura et al., 1999

Upon consumption, aspartame undergoes rapid hydrolysis in the small intestine, breaking down into its constituent components: aspartic acid (40%), phenylalanine (50%), and methanol (10%)

This was in confirmation of our earlier studies on different diabetic rat models ( At the center of the cellular response to oxidative stress is the keap 1-Nrf2-antioxidant response elements (ARE) pathway, which helps in the maintenance of cellular homeostasis and detoxification by regulating the expression of many antioxidant proteins (Yoh et al., 2008)