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Undermethylation leads to lower SAMe, therefore the SAMe needed is not available and histamine is increased

3.2.4 Current limitations and future directions First, most DEPs identified via omics screening lack in vivo functional validation using techniques such as CRISPR/Cas9 knockout, leading to unresolved discrepancies between in vitro and in vivo effects

In Chronic Rhinosinusitis (CRS), for instance, Lai et al

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Pancreatic and other digestive juices beyond the stomach can cause intestinal irritation and ulcers if patients smoke or take NSAIDs

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