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These include molecules and enzymatic regulators involved in the metabolism of glucose, arginine, tryptophan, glutamine, cysteine, lipids, ROS, and AMP-activated protein kinase (AMPK) (28) ( Figure 2 )

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Pyroptosis plays a role in containing infections and promoting immune clearance, but excessive or dysregulated pyroptosis has also been implicated in the pathogenesis of sterile inflammatory and autoimmune diseases