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They have been found in GH3 cell cultures where they significantly reduce the expression of gh mRNA and that of pituitary-specific positive transcription factor 1, consequently acting as inhibitors of GH production

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[ref] Related article : PAI-1 genetic variants MicroRNAs (miRNAs) are short strands of RNA that can bind to mRNA and prevent a gene from being expressed

Tesofensine (NS2330) is classified as a presynaptic serotoninnoradrenalinedopamine reuptake inhibitor