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Bile-derived circulating extracellular miR-30d-5p and miR-92a-3p as potential biomarkers for cholangiocarcinoma

Soboleva AV, Krasnoshtanova AA, Krylov IA

Potential strategies include the injection of ECM-degrading enzymes or systemic treatment with small molecules that upregulate lysosomal collagen degradation, either preceding or concurrent with Ras pathway inhibition

The cDNA was synthesised using M-MLV Reverse Transcriptase (Promega) and was 30-fold diluted with deionised water before use as a template in qRT-PCR

In conclusion, this study provides novel insight into the molecular processes involved in ferroptosis, as well as the regulatory network and therapeutic strategies for ferroptosis in lung carcinoma

Blood 88(10):383a, 1996