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TGF-beta-mediated Foxp3 gene expression is cooperatively regulated by Stat5, Creb, and AP-1 through CNS2

Obesity as the main inducer of a systemic low-level inflammation is a main susceptibility factor for T2DM

Used by patients who need to take more medicine at once

Preclinical studies showed no adverse effects across several organ systems including liver, spleen, lung, kidney, brain, thymus, prostate, and ovaries in studies up to 6 weeks

Overall, while these findings demonstrate promising neuroprotective effects, the pharmacokinetics, long-term biodistribution, and potential off-target toxicity of CQDs remain largely unexplored, highlighting the need for more relevant studies prior to clinical application

PMID:3755152 Das M et al