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LL-37 is a potential mitigator of chronic inflammatory conditions in both male and female reproductive systems, experimentally applied to infections that cause persistent pelvic inflammation

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The authors of one trial (95) included in the above-mentioned meta-analysis (89) noted that little cognitive decline was observed in the placebo group over their two-year trial, which may have limited their power to detect an effect of the B-vitamin intervention (95)

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These might be a better option for people with increased nutrient needs or those at a greater risk of deficiency, including individuals with medical conditions that affect absorption