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490 On the basis of the above findings, we can also predict patients specific responses to p53-targeted therapies and design more effective combination therapies via systems biology methods

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This specific bacterium metabolizes the primary BA chenodeoxycholic acid (CDCA) into iso-LCA, which subsequently accumulates in the liver ( 2.1.3 Myeloid-derived suppressor cells: bile acid-mediated regulation Myeloid-derived suppressor cells (MDSCs), a heterogeneous population of immature myeloid cells with strong immunosuppressive activity, play a pivotal role in tumor immune evasion and metastasis ( Among these, conjugated and secondary BAs, particularly taurocholic acid (TCA) and deoxycholic acid (DCA), exert notable effects on MDSCs

Regulation of Methionine Metabolism The enzymes involved in methionine metabolism are tightly regulated to maintain cellular homeostasis