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Adrenal Glands (Adrenal Cortex): These are a pair of glands located on top of each kidney

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In the case of doxorubicin-induced cardiotoxicity, catalpol ameliorates the condition by reducing oxidative stress, myocardial apoptosis, and autophagy through activation of the protein kinase B (AKT)/mammalian target of rapamycin (mTOR) pathway (Liu B

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However, the gene knockout of AMPK does not completely block the effects of metformin against cancer development, suggesting the presence of alternative mechanisms (57,59)