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Study Design This systematic review followed the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines and was registered in the Open Science Framework ( registered on 15 May 2025)

These two receptors are directly modulated by AMP-activated protein kinase (AMPK), an enzyme integral to lipid metabolism, which exerts its influence through phosphorylation mechanisms ( Mitogen-activated protein kinases (MAPKs) constitute a distinct family of serine-threonine protein kinases, which are activated by a variety of extracellular signals (Zhao et al., 2022a)

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Optimization also involves finding your ceiling, the concentration above which results plateau or decline

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