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Curr Oncol Rep 24:645650 Ekazan AE (2020) Chronic myeloid leukaemia and the use of tyrosine kinase inhibitors in the days of COVID-19 pandemic

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Impaired SPM biosynthesis and signaling contribute to sustained plaque macrophage activation, defective efferocytosis, and expansion of the necrotic core, whereas restoration of SPM pathways enhances apoptotic cell clearance and promotes a pro-resolving macrophage phenotype (61, 62, 106, 131)

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Some reported effects include slight headache or lightheadedness (due to GH release), or mild flushing

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When the adamantyl group is incorporated in small molecular drugs, not only can it influence the interactions between the small molecules and cell membrane, 681 but it also can improve the pharmacokinetics of small molecule drugs