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These findings suggested that once approved as a pharmaceutical agent, the Si-based agent could be highly expected to help alleviate the symptoms of UC because the range of efficacy of the Si-based agent was very wide

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The NFB and MAPK pathways are associated with the neuroinflammatory response of astrocytes and regulate the production of inflammatory cytokines, chemokines, extracellular matrix proteins, cell adhesion molecules, ROS, and inducible nitric oxide synthase (iNOS), which are involved in leukocyte infiltration, neuronal death, and demyelination (Colombo and Farina, 2016

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Various interventions targeting these inflammatory pathways show therapeutic potential

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