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Antioxidants help reduce the impact of oxidative stress, which is one driver of visible aging

Recently, a human gene mutation of PAPP-A2, a circulating and tissue protease with IGFBP-5 (and to some extent IGFBP-3) as its primary substrate (Gaudamauskes et al), was demonstrated to have a marked growth phenotype involving fetal and post-natal growth retardation in children in a consanguineous family (43)

Hughes, K., Antonsson,

Streimikyte P, Viskelis P (2022) Enzymes-assisted extraction of plants for sustainable and functional applications

Hair Thinning Associated with Caloric Deficit Significant caloric restriction and rapid weight loss are known triggers for telogen effluvium, a temporary but distressing form of hair shedding