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We direct the reader to other excellent reviews for more detailed explanations on these processes [13, 16, 17]

Activation of PI3K/Akt and MAPK pathways regulates Myc-mediated transcription by phosphorylating and promoting the degradation of Mad1

Meanwhile, ATP rapidly degrades to adenosine through pathways such as PI3K/Akt and MEK/ERK to regulate macrophage proliferation and induce adenosine accumulation to promote immune suppression (154)