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188 VascellariS.MelisM.PalmasV.PisanuS.SerraA.PerraD.et al (2021)

The drug had received breakthrough therapy designation

Phase 2 (weeks 9-16): Lean mass focus maintaining lower semaglutide dose, adding CJC-1295 + Ipamorelin for GH support, continuing BPC-157

Reducing the secretion of IL6 in elderly, either by (a) administration of sex steroids, (b) decreasing fat through diet and exercise, (c) improving nighttime sleep, and (d) controlling adequately chronic pain and inflammation with nonsteroidal antiinflammatory agents, may improve sleep, daytime alertness, and performance, and decrease the risk of common ailments of old age, e.g., metabolic and cardiovascular problems, cognitive disorders, and osteoporosis (118, 149, 150)

Some researchers overlap the two briefly during transition, but this should be approached with caution due to stacked GLP-1 and GIP receptor activation