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TUNEL staining revealed that the IDH1-R132H mutation significantly exacerbates cisplatin-induced PTC death, while Lip-1 pretreatment alleviates this cell death (Fig

Has no obvious blood toxicity and did not cause bone marrow suppression, which is manifested by no significant changes in white blood cells (WBC), red blood cells (RBC) and hemoglobin (HGB)

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Jain P, Kantarjian HM, Ghorab A, Sasaki K, Jabbour EJ, Nogueras Gonzalez G, Kanagal-Shamanna R, Issa GC, Garcia-Manero G, Kc D, Dellasala S, Pierce S, Konopleva M, Wierda WG, Verstovsek S, Daver NG, Kadia TM, Borthakur G , O'Brien S, Estrov Z, Ravandi F, Cortes JE