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Speaking from my personal experience with Generals case, I believe that stem cell therapy can help cats with CKD who suffer from mild uremia and inflammation, but may not provide much help to cats with severe uremia from long-term CKD

Bidirectional expression of CUG and CAG expansion transcripts and intranuclear polyglutamine inclusions in spinocerebellar ataxia type 8

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PMID: 31445908

Plasma and tissue GSH levels decline with age, while markers of oxidative damage increase, creating a "redox imbalance" implicated in the pathogenesis of age-related diseases [2][3][10][11]