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In metabolic research models, high-fat diets typically lead to hypertrophy (enlargement) of WAT cells and a slowdown in their metabolic rate

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This enhancement is achieved by rapidly inhibiting regulatory T (Treg) cells in draining lymph nodes, an effect observed not only in antigen-specific subsets but also across the bulk lymphocyte populationthereby creating a pro-immune microenvironment that facilitates the induction of an effective early GC response