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Moreover, as a rate-limiting enzyme, GCLC catalyzing activity is subject to feedback inhibition by GSH [11], and abnormal expression is closely related to tumor progression and drug resistance in different histological types of human cancers [12, 13]

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Rights and permissions About this article Cite this article Musar, A., McCullagh, K., Paul, A

72 h post supernatant transfer, cells were lysed to analyse replication in infected cells

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as an anti-ferroptotic factor that parallels the GSH system [82, 83]