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Gotto, Jr

These variations disrupt the interaction of flagellins TLR5 activation hotspot residues with the cavity of TLR5s LRR9 loop, thereby facilitating evasion of TLR5 detection (Kim et al., 2018)

Restoring it is a major research focus

While early research and patient experiences are encouraging, it is not a magic solution, and there is still much researchers are learning about its long-term effects and effectiveness