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TABLE 2 Key epidemiological and clinical studies on chronic constipation-depression comorbidity (section 3)

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Recently, Lozano and collaborators demonstrated that in melanoma patients treated with anti-PD-1 or anti-PD-1 and anti-CTLA-4 combination, two pretreatment factors in peripheral blood - activated CD4 memory T cell abundance and TCR diversity - were associated with severe irAEs development (79)

3.4 Metal chelation Metal ions are widely present in biological systems and participate in many key biochemical processes including material transport, energy conversion, information transmission and metabolic regulation (Maniscalchi et al., 2024)