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Abstract Oxidative stress, arising from an imbalance between reactive oxygen species (ROS) production and antioxidant defenses, is increasingly recognized as a pivotal driver of cancer initiation and progression

in fact, both mitochondrial fusion and membrane potential increase seem to have reached their maximum level at the early stage of the disease

This leads to IR, oxidative stress and inflammation through the release of inflammatory cytokinin promoting fat accumulation and tissue fibrosis [33, 35]

10.3390/biom14121524 [DOI] [PMC free article] [PubMed] [Google Scholar] Nacarkucuk E, Bernis ME, Bremer A-S, Grzelak K, Zweyer M, Maes E, Burkard H, Sabir H (2024) Neuroprotective effect of melatonin in a neonatal hypoxia-ischemia rat model is regulated by the AMPK/mTOR pathway

Their hydrophilic shell and nanoscale particle size facilitate drug release within the body and enhance drug concentration at the target site (181)

however, the red one is the tested model