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Some patients report feeling better for up to a week after treatment

Nelson DB, Rice DC, Niu J, Atay SM, Vaporciyan AA, Antonoff MB , Hofstetter WL, Walsh GL, Swisher SG, Roth JA, Tsao AS, Gomez DR, Giordano SH, Mehran RJ, Sepesi B

This indicates that oxidative stress may serve a central role in FOLFOX-induced SOS that can be prevented by the administration of the antioxidant butylated hydroxyanisole (10)

V.ChamseddineA.VelusamyP.et al (2025)

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However, in case of increased ROS production under stress conditions, such as biofilm growth or antibiotic treatment, the antioxidant mechanisms can be overwhelmed, leading to oxidative stress