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doi: 10.1038/nri.2017.9 2 DixonSJLembergKMLamprechtMRSkoutaRZaitsevEMGleasonCEet al

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These results demonstrate that metformin suppresses TXNIP expression through mitochondrial complex 1 inhibition, leading to the upregulation of GLUT1 expression and membrane localization in the ileum and colon, where it contributes to the glucotonic effect

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