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However, side effects and secondary drug resistance of these proteasome inhibitors limit their wide applications (Figure 1), and then discuss potential implication of copper complexes as new UPS inhibitors in cancer treatment

Additionally, we performed quantitative amino acid profiling of individuals from konzo-prone regions which suggests a deficiency in cystine, the precursor for the antioxidant glutathione, which is required by GPx3 to effectively remove ROS from circulation 22

Four to six weeks after separation the plants were used for experiments

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10a), and (2) extreme high light (~1500 mol m 2 s 1 ) combined with low CO 2 (~200 PPM for ~9 h and ~7080 PPM for ~55 h) for three days (Days 24, Fig