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For patients wanting a gentle, well-established GHRH peptide, sermorelin is often the starting point

The most common are dry mouth, trouble sleeping, irritability, a faster heart rate, and slightly higher blood pressure

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There are two main types of Cushings disease in dogs: Pituitary-dependent Cushings disease is the most common form of Cushings disease, where a tumor (usually benign) develops in the pituitary gland, causing it to produce excessive amounts of ACTH (adrenocorticotropic hormone), which in turn stimulates the adrenal glands to produce too much cortisol

PMID: 41680151 Nat Commun2025 Dec 12;16(1):11092