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There is also a practical reason

Recovery time Patients may feel numbness in the arms or legs just after the procedure along with other side effects related to the anesthetic component that usually settles down within 1-8 hours

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Second, we proposed to modify this cost measure to include additional sub-groups to stratify the patient cohort based on diagnosis to account for variations in cost and treatment pathways for inpatient procedures

Alterations in the levels of these modifications, as well as the presence of atypical modifications on certain residues, are associated with mutant and wildtype SOD1 misfolding (Figure 9)