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Recent evidence suggest that heme has a direct role in hemolysis-associated complement activation (Figure 3)

291 OksanenM.LehtonenS.JaronenM.GoldsteinsG.HmlinenR.KoistinahoJ

Flow cytometry and sorting For surface staining cells were incubated at 48 C, in the dark with fluorochrome-conjugated CD19, CD23, CD21-CD35 or CD35, IgD, IgM, CD1d, CD24, CD93, CD95, and GL-7 diluted 1:200 (refer to Supplementary Data 4 for details)

Unmapped electron-containing atoms or molecules initiate a sequence of reactions in which cells are damaged

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copper plays a crucial role in healthy bones, red blood cells production, iron absorption, the health of blood vessels, nerves, and the immune system