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Wainwright P (2017) Q&A: Metformin and vitamin B12 deficiency

During aging, GPAT activity was found to be blunted in murine T-lymphocytes [45], and GPAT1 deletion in T-lymphocytes induced a phenotype similar to that of aging [46]

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This depends on your nutritional needs but, generally, B vitamin supplements are formulated to provide much more than you need and this can be a problem for the three B vitamins that can cause toxicity niacin, folate and B-6