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Orphanet J Rare Dis 13:65

Some notable safety-related conclusions from scientific materials include: A 2016 review of TB4 for dermal healing: The safety profile is excellent, and no preclinical toxicology has been found.22 A 2016 clinical trial on patients with STEMI: Our pilot study suggested that T4-optimized EPC transplantation appeared to be feasible and safe.34 A 2021 review of TB4 research: It was well tolerated and safe in healthy people and suitable for use in a clinical study.21 Though the compound itself may be generally safe for adults to use, some common side effects from TB4 injections reported by patients and doctors include: Injection site reactions (e.g., redness, mild swelling, or pain) Mild gastrointestinal symptoms Headaches and dizziness Rare but more serious side effects can include fever, blistering at the injection site, muscle aches, skin rash, vomiting, severe itching, or hives

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As a consequence, the main mitochondrial proteome (~1500 proteins) is encoded by the nucleus, translated in the cytosol and imported into the mitochondria through specific translocator complexes (TIM and TOM) of the inner mitochondrial membrane (IMM) and outer mitochondrial membrane (OMM), respectively